XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis
Author:
Funder
Fonds Wetenschappelijk Onderzoek
Japan Agency for Medical Research and Development
Kyoto University
KU Leuven
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Hematology
Link
http://www.nature.com/articles/s41408-021-00409-3.pdf
Reference21 articles.
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2. Matsuoka, M. & Jeang, K. T. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat. Rev. Cancer 7, 270–280 (2007).
3. Fochi, S., Mutascio, S., Bertazzoni, U., Zipeto, D. & Romanelli, M. G. HTLV deregulation of the NF-kappaB pathway: an update on tax and antisense proteins role. Front. Microbiol. 9, 285 (2018).
4. P Pise-Masison, C. A. et al. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. J. Virol. 2, 1165–1170 (1998).
5. Watanabe, T. Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells. Blood 129, 1071–1081 (2017).
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