Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4
Author:
Funder
DH | National Institute for Health Research
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Hematology
Link
http://www.nature.com/articles/s41408-019-0173-0.pdf
Reference41 articles.
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2. Raza, S., Safyan, R. A. & Lentzsch, S. Immunomodulatory drugs (IMiDs) in multiple myeloma. Curr. Cancer Drug Targets 17, 846–857 (2017).
3. Ito, T. et al. Identification of a primary target of thalidomide teratogenicity. Science 327, 1345–1350 (2010).
4. Ito, T. & Handa, H. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int. J. Hematol. 104, 293–299 (2016).
5. Kronke, J. et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 343, 301–305 (2014).
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