NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF-Reference-Cited by-同舟云学术

NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF

Published:2006-12-10 Issue:1 Volume:13 Page:62-69
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Park Bae Keun,Zhang Honglai,Zeng Qinghua,Dai Jinlu,Keller Evan T,Giordano Thomas,Gu Keni,Shah Veena,Pei Lei,Zarbo Richard J,McCauley Laurie,Shi Songtao,Chen Shaoqiong,Wang Cun-Yu

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1519.pdf

Reference46 articles.

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2. Mundy, G.R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2, 584–593 (2002).

3. Javed, A. et al. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc. Natl. Acad. Sci. USA 102, 1454–1459 (2005).

4. Kozlow, W. & Guise, T.A. Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J. Mammary Gland Biol. Neoplasia 10, 169–180 (2005).

5. Zhang, J. et al. Osteoprotegerin inhibits prostate cancer–induced osteoclastogenesis and prevents prostate tumor growth in the bone. J. Clin. Invest. 107, 1235–1244 (2001).

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