Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy

Author:

Mukhopadhyay Anandaroop,Wright Jocelyn,Shirley Shawna,Canton David A.,Burkart Christoph,Connolly Richard J.,Campbell Jean S.,Pierce Robert H.ORCID

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference48 articles.

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2. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood. 1997;90:2541–8.

3. Hurteau JA, Blessing JA, DeCesare SL, Creasman WT. Evaluation of recombinant human interleukin-12 in patients with recurrent or refractory ovarian cancer: a gynecologic oncology group study. Gynecol Oncol. 2001;82:7–10.

4. Rosenberg SA. Cell therapy for metastatic melanoma using CD8 enriched tumor infiltrating lymphocytes. In: Health NIo, ed. ClinicalTrials.gov, 2015.

5. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK, et al. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol. 2008;26:5896–903.

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