The genetic and molecular regulation of sleep: from fruit flies to humans
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn2683.pdf
Reference154 articles.
1. Medori, R. et al. Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. N. Engl. J. Med. 326, 444–449 (1992). First study to show that a sleep disorder is caused by a gene mutation.
2. Tobler, I. et al. Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature 380, 639–642 (1996). First study in mice to show that a null mutation affects sleep regulation.
3. Tobler, I., Deboer, T. & Fischer, M. Sleep and sleep regulation in normal and prion protein-deficient mice. J. Neurosci. 17, 1869–1879 (1997).
4. Lin, L. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365–376 (1999). Seminal study that identified the autosomal recessive mutation responsible for canine narcolepsy.
5. Chemelli, R. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437–451 (1999). This study showed that mice lacking hypocretin/orexin have a narcolepsy-like phenotype.
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