Regulated insulin secretion from human and mouse islets exclusively composed of β-cells
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s42255-024-01117-5.pdf
Reference5 articles.
1. Bru-Tari, E., Oropeza, D. & Herrera, P. L. Cell heterogeneity and paracrine interactions in human islet function: a perspective focused in β-cell regeneration strategies. Front. Endocrinol. 11, 619150 (2020). This paper discusses the relevance of paracrine interactions within pancreatic islets.
2. Thorel, F. et al. Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss. Nature 464, 1149–1154 (2010). This paper shows that adult pancreatic α-cells can convert to insulin-producing cells after extreme β-cell loss.
3. Chera, S. et al. Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers. Nature 514, 503–507 (2014). This paper demonstrates that adult pancreatic δ-cells engage insulin expression upon insulin deficiency.
4. Perez-Frances, M. et al. Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Nat. Commun. 12, 4458 (2021). This paper shows that adult pancreatic γ-cells engage insulin production in the absence of β-cells.
5. Furuyama, K. et al. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature 567, 43–48 (2019). This paper shows that human α-cells induce insulin production and glucose-mediated insulin secretion in absence of β-cells.
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