Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://www.nature.com/articles/s42255-021-00364-0.pdf
Reference52 articles.
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2. Butler, A. E. et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102–110 (2003).
3. Zhou, Q. & Melton, D. A. Pancreas regeneration. Nature 557, 351–358 (2018).
4. Aguayo-Mazzucato, C. & Bonner-Weir, S. Pancreatic beta-cell regeneration as a possible therapy for diabetes. Cell Metab. 27, 57–67 (2018).
5. Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic beta cells are formed by self-duplication rather than stem cell differentiation. Nature 429, 41–46 (2004).
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