The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer-Reference-Cited by-同舟云学术

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The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer

Published:2020-11-30 Issue:12 Volume:2 Page:1401-1412
ISSN:2522-5812
Container-title:Nature Metabolism
language:en
Short-container-title:Nat Metab

Author:

Kim Jiyeon^ORCID,Lee Hyun Min,Cai Feng,Ko Bookyung,Yang Chendong,Lieu Elizabeth L.,Muhammad Nefertiti,Rhyne Shawn,Li Kailong^ORCID,Haloul Mohamed,Gu Wen^ORCID,Faubert Brandon^ORCID,Kaushik Akash K.,Cai Ling,Kasiri Sahba,Marriam Ummay,Nham Kien,Girard Luc,Wang Hui,Sun Xiankai,Kim James,Minna John D.^ORCID,Unsal-Kacmaz Keziban,DeBerardinis Ralph J.^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Cancer Institute

American Lung Association

V Foundation for Cancer Research

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

American Cancer Society

Cancer Prevention and Research Institute of Texas

Howard Hughes Medical Institute

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://www.nature.com/articles/s42255-020-00316-0.pdf

Reference50 articles.

1. Ji, H. et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807–810 (2007).

2. Calles, A. et al. Immunohistochemical loss of LKB1 is a biomarker for more aggressive biology in KRAS-mutant lung adenocarcinoma. Clin. Cancer Res. 21, 2851–2860 (2015).

3. Skoulidis, F. & Heymach, J. V. Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy. Nat. Rev. Cancer 19, 495–509 (2019).

4. Skoulidis, F. et al. STK11/LKB1 mutations and PD-1 inhibitor resistance in KRAS-mutant lung adenocarcinoma. Cancer Discov. 8, 822–835 (2018).

5. Racker, E., Resnick, R. J. & Feldman, R. Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes. Proc. Natl Acad. Sci. USA 82, 3535–3538 (1985).

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