Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
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Published:2022-02-28
Issue:2
Volume:4
Page:284-299
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ISSN:2522-5812
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Container-title:Nature Metabolism
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language:en
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Short-container-title:Nat Metab
Author:
Fasolino Maria, Schwartz Gregory W., Patil Abhijeet R.ORCID, Mongia Aanchal, Golson Maria L., Wang Yue J.ORCID, Morgan Ashleigh, Liu ChengyangORCID, Schug Jonathan, Liu JinpingORCID, Wu Minghui, Traum DanielORCID, Kondo Ayano, May Catherine L., Goldman NaomiORCID, Wang Wenliang, Feldman Michael, Moore Jason H., Japp Alberto S., Betts Michael R., Fasolino Maria, Schwartz Gregory W., Patil Abhijeet R., Mongia Aanchal, Golson Maria L., Wang Yue J., Morgan Ashleigh, Liu Chengyang, Schug Jonathan, Liu Jinping, Wu Minghui, Traum Daniel, Kondo Ayano, May Catherine L., Goldman Naomi, Wang Wenliang, Feldman Michael, Moore Jason H., Japp Alberto S., Betts Michael R., Faryabi Robert B., Naji Ali, Kaestner Klaus H., Vahedi Golnaz, Faryabi Robert B.ORCID, Naji Ali, Kaestner Klaus H.ORCID, Vahedi GolnazORCID,
Funder
U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health U.S. Department of Health & Human Services | NIH | Center for Information Technology Burroughs Wellcome Fund
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference67 articles.
1. Powers, A. C. Type 1 diabetes mellitus: much progress, many opportunities. J. Clin. Invest. https://doi.org/10.1172/JCI142242 (2021). 2. Michels, A. W., Redondo, M. J. & Atkinson, M. A. The pathogenesis, natural history, and treatment of type 1 diabetes: time (thankfully) does not stand still. Lancet Diabetes Endocrinol. https://doi.org/10.1016/S2213-8587(21)00344-2 (2021). 3. Boldison, J. & Wong, F. S. Immune and pancreatic beta cell interactions in type 1 diabetes. Trends Endocrinol. Metab. 27, 856–867 (2016). 4. Unanue, E. R. & Wan, X. The immunoreactive platform of the pancreatic islets influences the development of autoreactivity. Diabetes 68, 1544–1551 (2019). 5. Barrett, J. C. et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 41, 703–707 (2009).
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