A local source of insulin protects the retina against starvation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://www.nature.com/articles/s42255-023-00745-7.pdf
Reference5 articles.
1. Léveillard, T., Philp, N. J. & Sennlaub, F. Is retinal metabolic dysfunction at the center of the pathogenesis of age-related macular degeneration? Int. J. Mol. Sci. 20, 762 (2019). A review of metabolic dysfunction in retinal degeneration.
2. Hui, S. et al. Glucose feeds the TCA cycle via circulating lactate. Nature 551, 115–118 (2017). This paper reports that the brain is the only tissue that can take up glucose from circulation in fasting mice.
3. Penberthy, K. K. et al. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci. Rep. 7, 14623 (2017). This paper contains the RNA-seq data set from which our original observations on insulin in the eye began.
4. Reiter, C. E. N. et al. Characterization of insulin signaling in rat retina in vivo and ex vivo. Am. J. Physiol. Endocrinol. Metab. 285, E763–E774 (2003). This paper shows that insulin injected into the portal vein of rats does not affect insulin signalling in the retina.
5. Mazucanti, C. H. et al. Release of insulin produced by the choroid plexis is regulated by serotonergic signalling. JCI Insight 4, e131682 (2019). This paper shows that the choroid plexus epithelium of the brain can produce insulin.
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