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Beyond odds ratios — communicating disease risk based on genetic profiles

Published:2009-04 Issue:4 Volume:10 Page:264-269
ISSN:1471-0056
Container-title:Nature Reviews Genetics
language:en
Short-container-title:Nat Rev Genet

Author:

Kraft Peter,Wacholder Sholom,Cornelis Marilyn C.,Hu Frank B.,Hayes Richard B.,Thomas Gilles,Hoover Robert,Hunter David J.,Chanock Stephen

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology

Link

http://www.nature.com/articles/nrg2516.pdf

Reference51 articles.

1. Manolio, T. A., Brooks, L. D. & Collins, F. S. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 118, 1590–1605 (2008).

2. Rockhill, B., Newman, B. & Weinberg, C. Use and misuse of population attributable fractions. Am. J. Public Health 88, 15–19 (1998).

3. Thomas, G. et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nature Genet. 40, 310–315 (2008).

4. Zheng, S. L. et al. Cumulative association of five genetic variants with prostate cancer. N. Engl. J. Med. 358, 910–919 (2008).

5. Weedon, M. N. et al. Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med. 3, e374 (2006).

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