TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer

Author:

Kron Ken J,Murison Alexander,Zhou StanleyORCID,Huang VincentORCID,Yamaguchi Takafumi NORCID,Shiah Yu-JiaORCID,Fraser Michael,van der Kwast Theodorus,Boutros Paul CORCID,Bristow Robert G,Lupien MathieuORCID

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference78 articles.

1. Siegel, R.L., Miller, K.D. & Jemal, A. Cancer statistics, 2016. CA Cancer J. Clin. 66, 7–30 (2016).

2. Tomlins, S.A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644–648 (2005).

3. Cancer Genome Atlas Research Network. The molecular taxonomy of primary prostate cancer. Cell 163, 1011–1025 (2015).

4. Lin, B. et al. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res. 59, 4180–4184 (1999).

5. Clinckemalie, L. et al. Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element. Mol. Endocrinol. 27, 2028–2040 (2013).

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