Do inhibitory receptors need to be proximal to stimulatory receptors to function?
Author:
Funder
Wellcome Trust
GlaxoSmithKline
RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41435-023-00251-6.pdf
Reference10 articles.
1. Worboys JD, Vowell KN, Hare RK, Ambrose AR, Bertuzzi M, Conner MA, et al. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nat Commun. 2023;14:5016. https://doi.org/10.1038/s41467-023-40755-3.
2. Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med. 2012;209:1201–17. https://doi.org/10.1084/jem.20112741.
3. Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355:1428–33. https://doi.org/10.1126/science.aaf1292.
4. Egen JG, Allison JP. Cytotoxic T. lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity. 2002;16:23–35. https://doi.org/10.1016/s1074-7613(01)00259-x.
5. Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, et al. Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity. 2010;33:326–39. https://doi.org/10.1016/j.immuni.2010.09.006.
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