Gaining ground in personalized breast cancer therapy: lesson learned from PHERGain
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41571-024-00907-w.pdf
Reference10 articles.
1. Pérez-García, J. M. et al. 3-year invasive disease-free survival with chemotherapy de-escalation using an 18F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial. Lancet 403, 1649–1659 (2024).
2. Miglietta, F., Dieci, M. V., Griguolo, G. & Guarneri, V. Neoadjuvant approach as a platform for treatment personalization: focus on HER2-positive and triple-negative breast cancer. Cancer Treat. Rev. 98, 102222 (2021).
3. Llombart-Cussac, A. et al. HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial. Lancet Oncol. 18, 545–554 (2017).
4. Guarneri, V. et al. De-escalated therapy for HR+/HER2+ breast cancer patients with Ki67 response after 2-week letrozole: results of the PerELISA neoadjuvant study. Ann. Oncol. 30, 921–926 (2019).
5. Tolaney, S. M. et al. Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial. Lancet Oncol. 24, 273–285 (2023).
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