Emerging epigenetic-modulating therapies in lymphoma
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://www.nature.com/articles/s41571-019-0190-8.pdf
Reference154 articles.
1. Lunning, M. A. Mutation of chromatin modifiers; an emerging hallmark of germinal center B cell lymphoma. Blood Cancer J. 5, e361 (2015).
2. Morin, R. D. et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476, 298–303 (2011). This paper demonstrates that somatic mutations in genes encoding histone-modifying enzymes, including KMT2D and MEF2B, are frequent in DLBCL and FL.
3. Morin, R. D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B cell lymphomas of germinal-cell origin. Nat. Genet. 42, 181–184 (2010). This paper demonstrates that somatic mutations of EZH2 are frequent in GCB-like DLBCL and FL.
4. Pasqualucci, L. et al. Analysis of the coding genome of diffuse large B cell lymphoma. Nat. Genet. 43, 830–836 (2011). This study reveals that the coding genome of DLBCL typically contains more than 30 gene alterations per patient, including a high frequency of KMT2D mutations.
5. Pasqualucci, L. et al. Inactivating mutations of acetyltransferase genes in B cell lymphoma. Nature 471, 189–195 (2011).
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