Low-value approvals and high prices might incentivize ineffective drug development
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology
Link
http://www.nature.com/articles/s41571-018-0030-2.pdf
Reference10 articles.
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3. Gyawali, B. & Prasad, V. Drugs that lack single-agent activity: are they worth pursuing in combination? Nat. Rev. Clin. Oncol. 14, 193 (2017).
4. Carlisle, B. et al. Benefit, risk, and outcomes in drug development: a systematic review of sunitinib. J. Natl Cancer Inst. 108, djv292 (2016).
5. Zhu, A. X. et al. Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial. JAMA 312, 57–67 (2014).
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