β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/leu2016106.pdf
Reference40 articles.
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2. Weng AP, Ferrando AA, Lee W, JPt Morris, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269–271.
3. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated notch alleles. J Exp Med 1996; 183: 2283–2291.
4. Berquam-Vrieze KE, Swing DA, Tessarollo L, Dupuy AJ . Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1. Genesis 2012; 50: 112–118.
5. Chiang MY, Xu L, Shestova O, Histen G, L'Heureux S, Romany C et al. Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest 2008; 118: 3181–3194.
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