Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade-Reference-Cited by-同舟云学术

Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade

Published:2016-04-22 Issue:8 Volume:30 Page:1716-1724
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Suen H,Brown R,Yang S,Weatherburn C,Ho P J,Woodland N,Nassif N,Barbaro P,Bryant C,Hart D,Gibson J,Joshua D

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu201684.pdf

Reference59 articles.

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2. Motz GT, Coukos G . Deciphering and reversing tumor immune suppression. Immunity 2013; 39: 61–73.

3. Brown R, Pope B, Murray A, Esdale W, Sze DM, Gibson J et al. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10. Blood 2001; 98: 2992–2998.

4. Bryant C, Suen H, Brown R, Yang S, Favaloro J, Aklilu E et al. Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance. Blood Cancer J 2013; 3: e148.

5. Favaloro J, Brown R, Aklilu E, Yang S, Suen H, Hart D et al. Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state. Leuk Lymphoma 2014; 55: 1090–1098.

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