Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant-Reference-Cited by-同舟云学术

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Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant

Published:2016-05-25 Issue:1 Volume:31 Page:177-185
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Hamasy A,Wang Q,Blomberg K E M,Mohammad D K,Yu L,Vihinen M,Berglöf A,Smith C I E

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2016153.pdf

Reference69 articles.

1. Mohamed AJ, Yu L, Backesjo CM, Vargas L, Faryal R, Aints A et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev 2009; 228: 58–73.

2. Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M . The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. BioEssays 2001; 23: 436–446.

3. Yang WC, Collette Y, Nunes JA, Olive D . Tec kinases: a family with multiple roles in immunity. Immunity 2000 Apr; 12: 373–382.

4. Berglof A, Turunen JJ, Gissberg O, Bestas B, Blomberg KE, Smith CI . Agammaglobulinemia: causative mutations and their implications for novel therapies. Expert Rev Clin Immunol 2013; 9: 1205–1221.

5. Takata M, Kurosaki T . A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. J Exp Med 1996; 184: 31–40.

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