Exploring the universe of molecules for new drugs
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm0295-177.pdf
Reference4 articles.
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2. Bohacek, R.S., & McMartin, C., Multiple highly diverse structures complementary to enzyme binding sites: Results of extensive application of a de novo design method incorporating combinatorial growth. J. Am. chem. Soc. 116, 5560–5571 (1994).
3. Roderick, S.L., Fournie-Zaluski, B.P., Roques, B.P., & Matthews, B.W., Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin. Biochemistry 28, 1493–1497 (1989).
4. Bohacek, R.S., & McMartin, C., Definition and display of steric, hydrophobic and hydrogen bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: Validation of a high-resolution graphical tool for drug design. J. med. Chem. 35, 1671–1684 (1992).
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