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Association studies for finding cancer-susceptibility genetic variants

Published:2004-11 Issue:11 Volume:4 Page:850-860
ISSN:1474-175X
Container-title:Nature Reviews Cancer
language:en
Short-container-title:Nat Rev Cancer

Author:

Pharoah Paul D. P.,Dunning Alison M.,Ponder Bruce A. J.,Easton Douglas F.

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

http://www.nature.com/articles/nrc1476.pdf

Reference54 articles.

1. Houlston, R. S. & Peto, J. in Genetic predisposition to cancer (eds Eeles, R. A., Ponder, B. A. J., Easton, D. F. & Horwich, A.) 208–226 (Chapman & Hall, London, 1996).

2. Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer — analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78–85 (2000). A landmark paper reporting the heritability of the common cancers based on data from over 40,000 twin pairs from Scandinavia.

3. Easton, D. F. How many more breast cancer predisposition genes are there. Breast Cancer Res. 1, 14–17 (1999).

4. Antoniou, A. C. et al. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br. J. Cancer 86, 76–83 (2002).

5. Risch, N. Searching for genetic determinants in the new millenium. Nature 405, 847–856 (2000). An excellent description of the strengths and weaknesses of different methods for gene mapping in complex diseases.

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