Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry,Biotechnology
Link
https://www.nature.com/articles/s41592-023-01944-6.pdf
Reference44 articles.
1. Kristensen, L. S. et al. The biogenesis, biology and characterization of circular RNAs. Nat. Rev. Genet. 20, 675–691 (2019).
2. Hulstaert, E. et al. Charting extracellular transcriptomes in the Human Biofluid RNA Atlas. Cell Rep. 33, 108552 (2020).
3. Wang, S. et al. Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies. Mol. Cancer 20, 13. (2021).
4. Vromman, M. et al. Validation of circular RNAs using RT-qPCR after effective removal of linear RNAs by ribonuclease R. Curr. Protoc. 1, e181 (2021).
5. Yu, C. Y., Liu, H. J., Hung, L. Y., Kuo, H. C. & Chuang, T. J. Is an observed non-co-linear RNA product spliced in trans, in cis or just in vitro?. Nucleic Acids Res. 42, 9410–9423 (2014).
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