Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry,Biotechnology
Link
http://www.nature.com/articles/s41592-020-0821-0.pdf
Reference47 articles.
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2. Smart, O. S. et al. Validation of ligands in macromolecular structures determined by X-ray crystallography. Acta Crystallogr. D 74, 228–236 (2018).
3. Foster, S. R. et al. Discovery of human signaling systems: pairing peptides to g protein-coupled receptors. Cell 179, 895–908.e21 (2019).
4. Coman, C. et al. Simultaneous metabolite, protein, lipid extraction (simplex): a combinatorial multimolecular omics approach for systems biology. Mol. Cell. Proteom. 15, 1453–1466 (2016).
5. Laschet, C., Dupuis, N. & Hanson, J. The G protein-coupled receptors deorphanization landscape. Biochem. Pharmacol. 153, 62–74 (2018).
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