A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects-Reference-Cited by-同舟云学术

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Published:2020-05-18 Issue:6 Volume:17 Page:600-604
ISSN:1548-7091
Container-title:Nature Methods
language:en
Short-container-title:Nat Methods

Author:

Zuo Erwei^ORCID,Sun Yidi^ORCID,Yuan Tanglong^ORCID,He Bingbing^ORCID,Zhou Changyang^ORCID,Ying Wenqin^ORCID,Liu Jing^ORCID,Wei Wu^ORCID,Zeng Rong,Li Yixue^ORCID,Yang Hui^ORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biochemistry,Biotechnology

Link

http://www.nature.com/articles/s41592-020-0832-x.pdf

Reference36 articles.

1. Rees, H.A. & Liu, D.R. Base editing: precision chemistry on the genome and transcriptome of living cells. Nat. Rev. Genet. 19, 770–788 (2018).

2. Zuo, E. et al. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science 364, 289–292 (2019).

3. Jin, S. et al. Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science 364, 292–295 (2019).

4. Grunewald, J. et al. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors. Nature 569, 433–437 (2019).

5. Grünewald, J. et al. CRISPR adenine and cytosine base editors with reduced RNA off-target activities. 37, 1041–1048 (2019).

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