Structure-guided development of heterodimer-selective GPCR ligands-Reference-Cited by-同舟云学术

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Structure-guided development of heterodimer-selective GPCR ligands

Published:2016-07-26 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Hübner Harald,Schellhorn Tamara,Gienger Marie,Schaab Carolin,Kaindl Jonas,Leeb Laurin,Clark Timothy,Möller Dorothee,Gmeiner Peter

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms12298.pdf

Reference55 articles.

1. Kobilka, B. K. G protein coupled receptor structure and activation. Biochim. Biophys. Acta 1768, 794–807 (2007).

2. Bouvier, M. Oligomerization of G-protein-coupled transmitter receptors. Nat. Rev. Neurosci. 2, 274–286 (2001).

3. Ferre, S., Ciruela, F., Woods, A. S., Lluis, C. & Franco, R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends Neurosci. 30, 440–446 (2007).

4. George, S. R., O'Dowd, B. F. & Lee, S. P. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat. Rev. Drug Discov. 1, 808–820 (2002).

5. Han, Y., Moreira, I. S., Urizar, E., Weinstein, H. & Javitch, J. A. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat. Chem. Biol. 5, 688–695 (2009).

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