Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
http://www.nature.com/articles/ncb2578.pdf
Reference28 articles.
1. Laybutt, D. R. et al. Endoplasmic reticulum stress contributes to β cell apoptosis in type 2 diabetes. Diabetologia 50, 752–763 (2007).
2. Huang, C. J. et al. Induction of endoplasmic reticulum stress-induced β-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. Am. J. Physiol. Endocrinol. Metab. 293, E1656–E1662 (2007).
3. Fonseca, S. G. et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells. J. Biol. Chem. 280, 39609–39615 (2005).
4. Delmeire, D. et al. Type VIII adenylyl cyclase in rat β cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia 46, 1383–1393 (2003).
5. Marchetti, P. et al. The endoplasmic reticulum in pancreatic β cells of type 2 diabetes patients. Diabetologia 50, 2486–2494 (2007).
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