Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding

Author:

Osickova Adriana12,Balashova Nataliya3,Masin Jiri1,Sulc Miroslav12,Roderova Jana1,Wald Tomas14,Brown Angela C.5,Koufos Evan5,Chang En Hyung5,Giannakakis Alexander36,Lally Edward T.3,Osicka Radim1

Affiliation:

1. Institute of Microbiology of the CAS, v.v.i. Prague Czech Republic

2. Faculty of Science, Charles University Prague Czech Republic

3. Department of Pathology, School of Dental MedicineUniversity of Pennsylvania Philadelphia PA USA

4. Department of Orofacial Sciences and Program in Craniofacial BiologyUniversity of California San Francisco CA USA

5. Department of Chemical and Biomolecular EngineeringLehigh University Bethlehem PA USA

6. The Department of Cell and Molecular Biology at Karolinska Institutet Stockholm Sweden

Funder

Grantová Agentura České Republiky (Grant Agency of the Czech Republic)

Ministerstvo Školství, Mládeže a Tělovýchovy (Ministry of Education, Youth and Sports)

Univerzita Karlova v Praze (Charles University)

National Science Foundation (NSF)

U.S. Department of Health & Human Services | National Institutes of Health (NIH)

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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