Author:
Akinrinde Akinleye,Venter Maryna Van de,Koekemoer Trevor,Bradley Graeme
Abstract
Background: The roots of Dianthus thunbergii SS Hooper are used traditionally in South Africa for the treatment of
diabetes, wounds, colic, chest complaints and cancer. This study was aimed at investigating the potential anti-proliferative
activities of the D. thunbergii in mammalian cancer cell lines.
Materials and Methods: Aqueous and ethanol extracts of D. thunbergii were tested in vitro on two cancer cell lines:
human hepato-cellular carcinoma (HepG2) cells and murine insulinoma (INS-1) cells using the 3-(4,5-Dimethylthiazol-2-
yl) 2,5-diphenyltetrazolium bromide (MTT) and crystal violet cell viability assays, as well as live-cell fluorescence imaging
microscopy. A tentative profiling of the aqueous extract was also carried out using liquid chromatography-mass
spectrometry (LC-MS).
Results: The aqueous extract (50-200μg/ml) exhibited significant (p
Publisher
African Traditional Herbal Medicine Supporters Initiative (ATHMSI)
Subject
Complementary and alternative medicine,Drug Discovery
Cited by
4 articles.
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