The relationship of serotonin level with syndrome X and coronary artery disease

Abstract

Aims: Platelets secrete serotonin (5-hydroxytryptamine) which has several effects on the vascular wall and promotes thrombogenesis, mitogenesis, and proliferation of smooth muscle cells. We thought serotonin which relation with coronary artery disease (CAD) has been shown in various data might be important for etiology and diagnosis of cardiac syndrome X (CSX) which’s physiopathology has not been elucidated yet. The aim of the study is to investigate relationship between serotonin level with CSX and stabile coronary artery disease. Methods: Serum serotonin levels were measured by micro ELİSA procedure in three group of patients who underwent coronary angiography. First group consisted of 30 patients (17 male, 13 female, mean age 60.5±6.1) who has diagnosed CSX, second group consisted 22 patients (11 male, 11 female, mean age 60.5±6.1) who has diagnosed stable coronary artery disease and third group consisted 28 patients (10 male, 18 female, mean age 56.6±10) comprised the control group. All three groups of patients demographic, biochemical, hematological and echocardiographic data were recorded. Results: The three groups were similar with respect to age, sex, body mass index and the frequencies of diabetes mellitus and smoking(p>.016). We detected average serum serotonin levels 49.7 ng/ml in syndrome X group, 41.8 ng/ml in CAD group and 44.8 ng/ml in control group. These values are not statistically significant between the groups monitored(p=.91). Conclusion: The serotonin level of of CSX patients, stabile coronary artery disease patients and control group patients were measured in the serum which seperated from peripheral venous blood. Statistically significant difference in serum serotonin levels couldn’t be detected between these three group.