Relationship between lipid profile and monocyte to highdensity lipoprotein ratio with disease severity in chronic obstructive pulmonary disease patients

Abstract

Aim: To examine lipid profile and monocyte to high density lipoprotein ratio ratio (MHR) values in stable chronic obstructive pulmonary disease patients. Material and Method: Patients admitted to our hospital with the diagnosis of chronic obstructive pulmonary disease (COPD) between 01.01.2014 - 01.01.2020 were included in the study and evaluated retrospectively. According to the COPD guideline, two main groups were formed as A+B and C+D. Demographic characteristics, hemogram, C-Reaktif protein (CRP), albumin, lipid profile values were analyzed. Result: In our study, there were 360 cases, 293 (81.4%) of which were male. The mean age was 67.61±8.7 years. There were 162 cases (45%) in the A+B group and 198 (55%) in the C+D group.White blood cell (WBC) , neutrophil, lymphocyte, neutrophil/lymphocyte ratio (NLR), monocytes, hemoglobin, CRP, Albumin, high density lipoprotein (HDL), monocyte to HDL ratio (MHR) were found to be different at the level of statistical significance, while cholesterol, triglyceride and low density lipoprotein (LDL) were not at this level of significance. When evaluated with multivariate regression analysis afterwards, it was observed that the statistical significance levels of MHR, CRP and albumin values continued. Conclusion: We think that high MHR rate, high CRP, and low albumin values in stable COPD patients may be a stimulant for increased disease severity.