A new era in fundamentals of bone homeostasis: biocompatibility of bone mineral doped fluoride ions with osteoblast cells in the balance of calcium and phosphate metabolism

Abstract

Aim: The use of biocompatible bone tissue grafts, filling materials, bone minerals, and implants, particularly in medicine and dentistry studies, has expanded significantly in recent years, as have expectations from the materials. We aimed to test the biocompatibility and wound and tissue biocompatibility of many grafts and similar materials used in medicine and dentistry with tests such as cytotoxicity, scratch assay, cell adhesion, and hemolysis. Material and Method: In this study, the interaction of fluorine ions with a dental material was investigated by biological activity experiments. In addition, studies were carried out on important osteoblast cells for tissue regeneration control. For this process, cell migration analysis, which we do not encounter frequently in the literature, was used to examine the interaction of cells with biomaterials more sharply. Results: Flor ions do not create a cytotoxic effect and also increase the viability of osteoblasts which is important for tissue regeneration and are bone precursor cells. Conclusions: In this study, in which the efficiency of osteoblast cells was discussed, it was concluded that 2% fluorine added material had more effective biological results compared to the increase in fluorine ion ratio.