Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein-Reference-Cited by-同舟云学术

Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein

Published:2002-08-28 Issue:5 Volume:2 Page:264-277
ISSN:1359-4117
Container-title:Journal of Experimental Therapeutics and Oncology
language:en
Short-container-title:Journal of Experimental Therapeutics and Oncology

Author:

Zhu Wei-Yong,Bunni M.,Priest D. G.,DiCapua J. L.,Dressler J. M.,Chen Z.,Melera Peter W.

Publisher

Wiley

Subject

Cancer Research,Drug Discovery,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1046/j.1359-4117.2002.01049.x/fullpdf

Reference60 articles.

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4. Head and neck cancer: III. Toxicity of 24 hour infusions of methotrexate and protection by leucovorin in patients with epidermoid carcinomas.;Lefkowitz;Cancer Chemother Rep,1967

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