1. National Institute for Clinical Excellence. Appraisal of New and Existing Technologies: Interim Guidelines for Manufacturers and Sponsors, 1999. Available at http://www.nice.org.uk. First accessed January 1, 2000. Revised guidance has now been published: National Institute for Clinical Excellence: Technical Guidance for Manufacturers and Sponsors on Making a Submission to a Technology Appraisal, 2001. Available at http://www.nice.org.uk. First accessed March 1, 2001.