In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity

Author:

De Clerck Fred,Van de Water Andre,D'Aubioul Jan,Lu Hua Rong,van Rossem Koen,Hermans An,Van Ammel Karel

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference51 articles.

1. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology

2. Congenital and acquired long QT syndrome

3. QT interval prolongation by noncardiovascular drugs: A proposed assessment strategy

4. 4 Anonymous . Points to Consider: the assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products . Publication no. CPMP 986-996. Committee for Proprietary Medicinal Products (CPMP) Human Medicines Evaluation Unit, London, UK, 1997 .

5. Screening lead compounds for QT interval prolongation

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