Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging
Author:
Publisher
Wiley
Subject
Cell Biology,Ageing
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1046/j.1474-9728.2003.00034.x/fullpdf
Reference45 articles.
1. Relationship of Genotype to Phenotype in Fibroblast-derived Transmitochondrial Cell Lines Carrying the 3243 Mutation Associated with the Melas Encephalomyopathy: Shift towards Mutant Genotype and Role of mtDNA Copy Number
2. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
3. The Frequency of Heteroplasmy in the HVII Region of mtDNA Differs across Tissue Types and Increases with Age
4. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection
5. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.
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