Effects of 5-Hydroxytryptamine and Ergotamine on Human Superficial Temporal Artery-Reference-Cited by-同舟云学术

Effects of 5-Hydroxytryptamine and Ergotamine on Human Superficial Temporal Artery

Published:1981-12 Issue:4 Volume:1 Page:223-228
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Østergaard J. R.¹,Mikkelsen E.¹,Voldby B.¹

Affiliation:

1. J. F. Østergaard and E. Mikkelsen, Department of Clinical Pharmacology, University of Aarhus, 8000 Aarhus, Denmark,' B. Voldby, Department of Neurosurgery, University of Aarhus, 8000 Aarhus, Denmark.

Abstract

Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10–5 M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1981.0104223.x

Reference27 articles.

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