Urinary 5–HIAA in Migraine: Evidence of Lowered Excretion in Young Adult Females

Author:

Bousser Marie-Germaine1,Elghozi Jean-Luc1,Laude Dominique1,Soisson Thierry1

Affiliation:

1. Marie-Germaine Bousser, Thierry Soisson, Clinic for Diseases of the Nervous System, Hôpital de la Salpêtrière, 47 Bd del' Hôpital, 75651 Paris Cedex 13: Jean-Luc Elghozi, Dominique Laude, Pharmacology Laboratory, INSERM U7. Faculty of Medicine Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France;

Abstract

Urinary 5–hydroxyindoleacetic acid (5–HIAA) and homovanillic acid (HVA) were determined in 44 young adult migraine patients (35 women, 9 men) between attacks and in 33 healthy controls (23 women, 10 men). HVA excretion was equivalent in all groups. 5–HIAA was unaltered in men but was significantly decreased in female migraine patients when compared with their sex-matched controls (-31%, p < 0.01). No relationship was found between 5–HIAA excretion and the various characteristics of migraine, such as the time that had elapsed since the last attack and the presence or absence of oral contraception. The relatively marked decrease in 5–HIAA excretion in female migraine patients can hardly be accounted for by a reduction in either neuronal or platelet serotonin metabolism alone. A reduction in the intestinal contribution to urinary 5–HIAA might be the crucial factor.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

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