Affiliation:
1. Center for the Study of Headache and Cranial Neuralgia, Institute of Neurology and Chair of Clinical Biochemistry1
Abstract
We describe the method of31phosphorous magnetic resonance spectroscopy and review the results when it is applied to the study of brain and muscle energy metabolism in migraine subjects. Brain energy metabolism appears to be abnormal in all major subtypes of migraine when measured both during and between attacks. Impaired energy metabolism is also documented in skeletal muscle. We suggest that migraine is associated with a generalized disorder of mitochondrial oxidative phosphorylation and that this may constitute a threshold for the triggering of migraine attacks.
Subject
Neurology (clinical),General Medicine
Cited by
66 articles.
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