Platelet Nitric Oxide Metabolites in Migraine-Reference-Cited by-同舟云学术

Platelet Nitric Oxide Metabolites in Migraine

Published:1999-05 Issue:4 Volume:19 Page:218-222
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Shimomura T¹,Murakami F¹,Kotani K²,Ikawa S¹,Kono S¹

Affiliation:

1. Department of Clinical Laboratory Medicine, Tottori University, Faculty of Medicine, Yonago, Japan

2. Department of Internal Medicine, Akasaki Public Clinic, Akasaki, Japan

Abstract

Nitric oxide (NO) is a candidate as a causative molecule in migraine. We determined nitrite, total nitrate/nitrite, and cyclic guanosine 3',5'-monophosphate (cGMP) concentrations in platelets from 30 migraine without aura (MwoA) patients and 17 migraine with aura (MwA) patients. All migraine patients were studied during their migraine attacks. The control group consisted of 28 healthy volunteers. Concentrations of platelet nitrite and total nitrate/nitrite were determined using simple and sensitive nitrate/nitrite fluorometric assay techniques. High concentrations of platelet nitrite and total nitrate/nitrite were found in patients with MwoA and MwA when compared with healthy controls. High concentrations of platelet cGMP were also found in patients with MwoA and MwA. The levels of platelet total nitrate/nitrite significantly decreased in headache-free periods after treatment with oral propranolol. These findings suggest that NO is produced in platelets during migraine attacks. It maylilso be related to the migrainous pain and the changes in cerebral blood flow experienced during migraine attacks. These data may provide new strategies for the treatment of migraine.

Publisher

SAGE Publications

Subject

Clinical Neurology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1999.019004218.x

Reference21 articles.

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