The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase
Author:
Publisher
Wiley
Subject
Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1046/j.1432-1033.2002.02857.x/fullpdf
Reference20 articles.
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2. Penicillin acylase has a single-amino-acid catalytic centre;Duggleby;Nature,1995
3. Penicillin acylase in the industrial production of β-lactam antibiotics;Bruggink;Org. Proc. Res. Dev.,1998
4. Acyl group transfer by proteases forming an acylenzyme intermediate: kinetic model analysis (including hydrolysis of acylenzyme- nucleophile complex);Gololobov;J. Theor. Biol.,1989
5. Enantioselective penicillin acylase-catalyzed reactions. Factors governing substrate and stereospecificity of the enzyme;Svedas;Ann. NY Acad. Sci.,1996
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