Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania

Author:

Jelinek T.1,Jelinek T.2,Rønn A. M.3,Lemnge M. M.4,Curtis J.1,Mhina J.4,Duraisingh M. T.1,Bygbjerg I. C.3,Warhurst D. C.1

Affiliation:

1. London School of Hygiene and Tropical Medicine, Department of Medical Parasitology, London, UK,

2. Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany,

3. Centre of Medical Parasitology, Unit of Tropical Medicine, Department of Infectious Diseases, State University Hospital, Rigshospitalet, Copenhagen, Denmark,

4. National Institute for Medical Research, Amani Research Centre, Amani, Tanzania

Publisher

Wiley

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Parasitology

Reference20 articles.

1. Basic Malaria Microscopy. World Health Organisation Geneva.

2. Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmissionWHO/MAL/96.1077. World Health Organisation Geneva.

3. Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum

4. Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, Plasmodium falciparum, with Differing Resistance to Sulfadoxine

5. Observations on monthly pyrimethamine (‘Daraprim’) prophylaxis in an East African village.;Clyde D;East African Medical Journal,1954

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