Evidence for a critical role of DNA topoisomerase IIα in drug sensitivity revealed by inducible antisense RNA in a human leukaemia cell line

Author:

Towatari Masayuki1,Adachi Koichi1,Marunouchi Tohru2,Saito Hidehiko13

Affiliation:

1. First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan,

2. Division of Cell Biology, Comprehensive Medical Institute, Fujita Health University, Toyoake, Aichi, Japan,

3. Aichi Blood Disease Research Foundation, Nagoya 463, Japan

Publisher

Wiley

Subject

Hematology

Reference22 articles.

1. Mechanisms of resistance to drugs that inhibit DNA topoisomerases;Beck W.T.;Seminars in Cancer Biology,1991

2. Drug resistance associated with altered DNA topoisomerase II

3. Teniposide‐resistant CEM cells, which express mutant DNA topoisomerase IIα, when treated with non‐complex‐stabilizing inhibitors of the enzyme, display no cross‐resistance and reveal aberrant function of the mutant enzyme;Chen M.;Cancer Research,1993

4. Vectors for Expression and Amplification of cDNA in Mammalian Cells: Expression of Rat Phenylalanine Hydroxylase

5. Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

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