Up-regulation of the granulocyte adhesion molecule Mac-1 by autoantibodies in autoimmune vasculitis

Author:

Johnson P A1,Alexander H D2,McMillan S A1,Maxwell A P3

Affiliation:

1. Department of Immunology

2. Department of Haematology

3. The Regional Nephrology Unit, Belfast City Hospital, Belfast, UK

Abstract

SUMMARY The characteristic finding of autoantibodies in patients with vasculitis has raised the possibility that these antibodies play a role in the pathogenesis of the disease. The expression of adhesion molecules (AM) on leucocytes and endothelial cells is believed to be integral to the development of vasculitis. We therefore investigated the effect of sera, positive for anti-neutrophil cytoplasmic antibodies (ANCA) or anti-nuclear antibodies (ANA) from patients with vasculitis, on granulocyte expression of the adhesion molecule Mac-1 (CD11b). Autoantibody-positive sera from 15 out of 35 patients with vasculitis stimulated an up-regulation of Mac-1 on granulocytes. In most cases this effect was reproduced by the autoantibody-positive purified IgG fraction. Autoantibody-negative samples did not stimulate AM up-regulation. Of interest, preincubation of sera with purified antigens did not inhibit AM up-regulation by the autoantibody samples. Blocking the Fc receptors on granulocytes did result in a decrease of Mac-1 up-regulation, but this trend was not statistically significant. These results suggest that both ANCA and ANA have the capacity to up-regulate granulocyte AM expression, and that while Fc interaction with granulocyte Fc receptors is important, it is not the only mechanism whereby such autoantibodies activate cells.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. ANCA-associated vasculitis;Nature Reviews Disease Primers;2020-08-27

2. Autoimmune Disease in the Kidney;The Autoimmune Diseases;2014

3. Immunological Aspects of Systemic Vasculitis;Systemic Vasculitis;2011

4. Das pulmorenale Syndrom auf der Intensivstation;Der Pneumologe;2010-09-29

5. Pathogenesis of ANCA-associated Vasculitis;Rheumatic Disease Clinics of North America;2010-08

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