Changing jejunal γδ T cell receptor (TCR)-bearing intraepithelial lymphocyte density in coeliac disease

Author:

ILTANEN S1,HOLM K12,ASHORN M2,RUUSKA T2,LAIPPALA P34,MÄKI M12

Affiliation:

1. Institute of Medical Technology, University of Tampere

2. Department of Paediatrics, Tampere University Hospital

3. Department of Public Health, Biometry Unit, University of Tampere

4. Tampere University Hospital, Tampere, Finland

Abstract

SUMMARY The function of jejunal intraepithelial γδ+ T cells is obscure, but they are commonly implicated as playing a role in inflammatory and autoimmune conditions. In coeliac disease (CoD), there are controversial reports as to gluten dependency of these cells. We have now studied the small bowel mucosal intraepithelial T cell densities, and the ratios of γδ+ to CD3+ T cells and γδ+ to αβ+ T cells during early disease development and on a gluten-free diet. Nine children initially excluded for CoD were followed up and rebiopsy after 0.8–4.5 years showed mucosal deterioration. Further, 21 biopsy specimens from newly diagnosed CoD patients were studied, together with 20 specimens taken from children on a gluten-free diet. During CoD development the density of γδ+ and αβ+ T cells as well as the ratios of γδ+ to CD3+ T cells and γδ+ to αβ+ T cells increased. In the latent stage of CoD when the small bowel mucosal architecture was still normal, two children had clearly normal densities of γδ+ (< 2.5 cells/100 epithelial cells) and αβ+ (< 25.0 cells/100 epithelial cells) T cells, and low ratios as well. In patients with newly diagnosed CoD the densities decreased significantly on a long-term gluten-free diet. We conclude that the density of intraepithelial γδ+ T cells as well as αβ+ T cells in CoD is gluten-dependent. CoD can develop in a child ingesting normal amounts of gluten and having normal jejunal mucosal morphology on biopsy and a normal density of γδ+ T cells.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3