Apoptosis of Th1-like cells in experimental tuberculosis (TB)-Reference-Cited by-同舟云学术

Apoptosis of Th1-like cells in experimental tuberculosis (TB)

Published:1999-02 Issue:2 Volume:115 Page:324-328
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

DAS G¹,VOHRA H²,SAHA B³,AGREWALA J N⁴,MISHRA G C¹

Affiliation:

1. National Centre for Cell Sciences, Ganeshkhind, Pune

2. Postgraduate Institute for Medical Education and Research, Chandigarh, India

3. Naval Medical Research Institute, Bethesda, MD, USA

4. Institute of Microbial Technology, Chandigarh, India

Abstract

SUMMARY Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-γ) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/115/2/324/42207719/j.1365-2249.1999.00755.x.pdf

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