Impaired expression of MHC class II molecules in response to interferon-gamma (IFN-γ) on human thymoma neoplastic epithelial cells

Author:

INOUE M12,OKUMURA M1,MIYOSHI S1,SHIONO H1,FUKUHARA K1,KADOTA Y1,SHIRAKURA R2,MATSUDA H1

Affiliation:

1. First Department of Surgery

2. Division of Organ Transplantation Biomedical Research Centre, Osaka University Medical School, Osaka, Japan

Abstract

SUMMARY A human thymoma is a neoplasm derived from the thymic epithelial cell, and is well known for its association with autoimmune diseases, especially myasthenia gravis. The neoplastic epithelial cells of thymoma clearly retain thymic epithelial functions, but the development of T cells in thymoma is somewhat impaired. In this study, we quantified by flow cytometry the in vitro expression of MHC molecules on neoplastic epithelial cells precultured with IFN-γ. While MHC class I expression was comparable with that on normal thymic epithelial cells, the level of MHC class II molecules on neoplastic epithelial cells was lower than in controls, and also varied greatly from case to case. Additionally, there was a significant positive correlation between the expression level of MHC class II and the proportion of mature CD3+ cells in the CD4+CD8− subset. Thus, accumulation of CD3−CD4+CD8− cells in thymoma may result from impaired expression of the MHC class II molecules, suggesting that the function of the neoplastic epithelial cells might determine the maturation and the positively selected repertoire of T cells in thymomas.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Reference39 articles.

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