Affiliation:
1. Department of Medical Microbiology and Immunology, University of Aarhus
2. Department of Clinical Microbiology, Aarhus Municipal Hospital, Denmark
3. Department of Infectious Diseases, Marselisborg Hospital
Abstract
SUMMARY
Infection of human monocyte-derived macrophages with CMV decreased the respiratory burst when cells were stimulated with opsonized zymosan or Pneumocystis carinii (P. carinii). Such an effect, though smaller, was also seen with heat-inactivated CMV, but only when triggered by zymosan. The effect was most pronounced in cells obtained from CMV antibody-negative donors. Dexamethasone further reduced the respiratory burst, both in uninfected and CMV-infected cells. Interferon-γ increased the response in uninfected cells and, to a lesser extend, in cells treated with heat-inactivated CMV, whereas no effect was seen with infective CMV. No overt productive infection or cytopathology could be detected, however, the monocytes incubated with infective but also heat-inactivated CMV formed clusters, a phenomenon that was equally pronounced in cultures from CMV antibody positive and negative-donors. These results might help explain the worse prognosis of P. carinii pneumonia in patients coinfected with CMV and receiving dexamethasone.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Cited by
25 articles.
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