Antiphosphatidylserine antibodies are elevated in normal tension glaucoma

Author:

Kremmer S1,Kreuzfelder E2,Klein R3,Bontke N1,Henneberg-Quester K B4,Steuhl K P1,Grosse-Wilde H2

Affiliation:

1. Abteilung für Erkrankungen des vorderen Augenabschnittes, Germany

2. Institut für Immunologie, Universitätsklinikum Essen, Germany

3. Innere Medizin II, Eberhard-Karls-Universität, Tübingen, Germany

4. Institut für 
Transfusionsmedizin, Universitätsklinikum Essen, Essen, Germany

Abstract

Summary The two main entities of open-angle glaucoma are primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG). Both diseases may be associated with autoimmune processes. Therefore, IgG and IgM antibodies to phospholipids (APL) and their subspecies cardiolipin (ACL), phosphatidylserine (APS) and β2-glycoprotein (β2GP) were determined in 43 NTG patients, 40 POAG patients and 40 healthy controls in a prospective study. The most prominent observation was the increase in APS concentrations in NTG patients (IgG 20·6 ± 2·7 U/ml, IgM 24·4 ± 3·4 U/ml) compared with POAG patients (IgG 8·8 ± 1·2 U/ml, IgM 11·0 ± 1·7), and controls (IgG 7·7 ± 1·3 U/ml, IgM 12·8 ± 1·5 U/ml). APS may be important due to their binding specificity to phosphatidylserine molecules which become accessible during apoptosis; this in turn may lead to local thrombosis.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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