The p53 status in juvenile chronic arthritis and rheumatoid arthritis-Reference-Cited by-同舟云学术

The p53 status in juvenile chronic arthritis and rheumatoid arthritis

Published:2000-11 Issue:2 Volume:122 Page:264-269
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Taubert H¹,Thamm B²,Meye A¹,Bartel F¹,Rost A-K²,Heidenreich D¹,John V³,Brandt J⁴,Bache M⁵,Würl P⁶,Schmidt H¹,Riemann D⁷

Affiliation:

1. Institute of Pathology, Martin Luther University Halle-Wittenberg, Halle/Saale

2. Institute of Human Genetics, University of Leipzig, Leipzig

3. Department of Children’s Rheumatology, Martin Luther University Halle-Wittenberg, Halle/Saale

4. Clinic of Orthopedic Surgery, Martin Luther University Halle-Wittenberg, Halle/Saale

5. Department of Radiotherapy, Martin Luther University Halle-Wittenberg, Halle/Saale

6. Surgical Clinic 1, University of Leipzig, Leipzig and

7. Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany

Abstract

SUMMARY The aim of this study was to investigate the p53 status in two autoimmune diseases; juvenile chronic arthritis (JCA) and rheumatoid arthritis (RA). In a PCR-sequencing analysis of exons 4–9 of the p53 gene, no mutation was identified, except for the case of an RA synovectomy sample with two mutations of intron 7. p53 gene polymorphisms for codons 36, 47, and 213 were not detected. Codon 72 polymorphism showed an indication of an increased occurrence of the Pro/Pro allelotype in JCA. Expression of P53 protein was comparable for JCA and RA synovectomy samples. For all RA samples P53 protein was detectable, whereas one sample of a JCA patient failed to express P53 protein.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/122/2/264/42134619/j.1365-2249.2000.01358.x.pdf

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