Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

Author:

Rengelshausen Jens,Göggelmann Christoph,Burhenne Jürgen,Riedel Klaus-Dieter,Ludwig Jochen,Weiss Johanna,Mikus Gerd,Walter-Sack Ingeborg,Haefeli Walter E.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. Digoxin-macrolide drug interaction;Bizjak;Ann Pharmacother,1997

2. Clarithromycin-induced digoxin toxicity: a case report and a review of the literature;Xu;Conn Med,2001

3. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy;Lindenbaum;N Engl J Med,1981

4. Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein;Wakasugi;Clin Pharmacol Ther,1998

5. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1);Tanigawara;J Pharmacol Exp Ther,1992

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